Productivity Drugs: Adderall Abuse

Productivity Drugs: Adderall Abuse    Adderall is a combination of amphetamine aspartate, amphetamine sulfate, dextroamphetamine saccharate, and dextroamphetamine sulfate. It is used in the treatment of Attention Deficit Hyperactivity Disorder (ADHD) which is when an individual (often children) are hyperactive-impulsive or have inattentive symptoms resulting in significant impairment to social, academic, or occupational functions. Individuals[…]

The Fury around Benzofury: 5-APB and 6-APB

The Fury around Benzofury:  5-APB and 6-APB The phenylethylamines 5-APB (1-(benzofuran-5-yl)-propan-2-amine) and 6-APB (1-(benzofuran-6-yl)-propan-2-amine) (aka “Benzo Fury”, “Benzofury”, 5-APB, 6-APB) are two of many new psychoactive substances making the news.1-3, 7-9 The prevalence of use is unclear as these compounds are often taken with other drugs. The compounds have been detected in individuals presenting with[…]

Why the ‘NBOMe’ compounds are not “The Bomb”

Why the ‘NBOMe’ compounds are not “The Bomb” The psychoactive phenethylamines ‘NBOMe’ compounds have hit the streets of United States with quite an explosion. Numerous hospitalizations and even deaths have been attributed to the use of these drugs. There are numerous variations of these compounds including 2-(4-iodo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine (25I-NBOMe; 2C-I-NBOMe; 25I; Cimbi-5), 2-(4-chloro-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine (25C-NBOMe; 2C-C-NBOMe; 25C;[…]

Phencyclidine-Has The “Dust” Been Stirred Up?

Phencyclidine-Has The “Dust” Been Stirred Up? Phencyclidine (PCP) or 1-(1-phenylcyclohexyl)piperidine), a dissociative drug known by the street name “Angel Dust”, was first synthesized by Parke, Davis and Company in 1926 for use in general anesthesia both in human and veterinary medicine.1 By the mid 1960’s its use was abandoned when patients in clinical studies experienced[…]

Designer Drugs: N-benzylpiperazine (BZP) and 1-(3-trifluoromethylphenyl)piperazine (TFMPP)

Designer Drugs: N-benzylpiperazine (BZP) and 1-(3-trifluoromethylphenyl)piperazine (TFMPP) With the influx of designer drugs readily available via Internet sources laboratories across the United States are seeing an increase in cases containing these substances. N-benzylpiperazine (BZP) and 1-(3-trifluoromethylphenyl) piperazine (TFMPP) are phenylpiperazine analogues and just two of the numerous compounds available that are often referred to as[…]

Ketamine: Not Your Average “Special K”

Ketamine: Not Your Average “Special K” Recently I had the honor to present at the joint meeting of the Southwestern and California Associations of Toxicologists on the use of ketamine in pediatric cases. Ketamine has a long history as a pharmaceutical agent for both human and veterinary medicine as an anesthetic agent in emergency medicine.[…]

On the Trail of Poison Mysteries (Popular Mechanics, 1929)

On the Trail of Poison Mysteries by Paul D. Paddock (Popular Mechanics, 1929) This is an interesting article on of the early role of Forensic Toxicology in criminal investigations. An excerpt “Poisons and mysterious deaths have been linked in the public mind since the dawn of history but modern chemical science has done much to[…]

Restoring Invisible and Abandoned Trials (RIAT) Proposal

Restoring Invisible and Abandoned Trials (RIAT) Proposal Restoring Invisible and Abandoned Trials (RIAT) proposal published in the British Medical Journal suggests that all clinical trials including those that are abandoned or considered “invisible” be published.1 “Invisible trials are those that have never been published. Abandoned trials are unpublished trials that sponsors are no longer actively[…]

Prescription Medication Use in the Elderly

Prescription Medication Use in the Elderly Per the Substance Abuse and Mental Health Services Administration (SAMHSA) 3 out of 10 people between the ages of 57 to 85 use 5 prescription medications or more.1 What is alarming about this statistic is over the next decade, individuals over 50 abusing prescription drugs could increase 190% to[…]